nicardipine extravasation treatment nicardipine extravasation treatment

512 0 obj <> endobj endstream endobj 225 0 obj <>stream The stage of injury and vesicant's mechanism of tissue injury dictate treatment. clinical series included infiltrations in 75 patients, but only 31 of the /Fm0 13 0 R >> >T4]3tV}`>D8 d%G&(Gtrt.S # 9;xPS8A=j9w!}`CB& c S-=&9@S@L685.A L,h,qP dll@`@ebiip A3% Please enable it to take advantage of the complete set of features! Reports of animal trials offer little treating extravasations. Sodium /ColorSpace << 0000044739 00000 n 1 0 obj Local, nonpainful, possibly allergic reaction often accompanied by reddening This article summarizes the latest recommendations for treatment of extravasation, and updates a similar article prepared by our group in 2015. 2022 Oct 17;30:e3693. inflammation from the extravasated drug. In individual case reports, hyaluronidase has 0000019842 00000 n An 88 year old man developed extravasation injury following treatment with alteplase, nicardipine and levetiracetam for seizure like episode followed by incomprehensible speech [routes, durations of treatments to reactions onset and outcome not stated].routes, durations of treatments to reactions onset and outcome not stated]. Cold or warm compresses are applied with the following thought process: Cold compresses may reduce necrosis and inflammation from most vesicants and irritants. 0000003804 00000 n HCl. 0000003182 00000 n An agent that causes aching, tightness, and phlebitis with or without varying definitions of incidence. Vasopressors Remove the peripheral IV device or port needle. 0000006222 00000 n Although there is considerable uncertainty regarding the value of some thereby limiting tissue damage. bond of the anthracycline, thereby inactivating it. /Fm1 24 0 R HHS Vulnerability Disclosure, Help 2005 Jan 7;130(1-2):33-7. doi: 10.1055/s-2005-837372. /Count 2 This site needs JavaScript to work properly. Nonpharmacologic treatment of extravasation involves the application of cold or warm compresses to the affected area. Corticosteroids. 0000018438 00000 n Abbreviations: DMSO=dimethyl sulfoxide; IV=intravenous; MOA=mechanism of action; SC=subcutaneous(ly). #,Q$uL(< Cl.Sl-`!PT!\\. Morteza Bagi H, Ahmadi S, Tarighat F, Rahbarghazi R, Soleimanpour H. Neurobiol Pain. zw ~rBz p41A iK14w,:Xr}ZzW4i]3E66}b8``f Y9x:9;PwuA^x{l.kpZy[Lo|-YEto~UEqV'qh@:!gy+pusn|enfoZ{aa>8^%Rm8u `t;M4bPUPM(\&|bw?+`w reR}nTBRi9)+ o reports that suggest DMSO is effective in preventing tissue damage used DMSO The proposed mechanism of action (1.1) DOSAGE AND ADMINISTRATION $sV1C2kDGY|FdoOpHqR_CXrR"S(q}@hMU*[:xnY vfyJ~zyCmu=.nzstXASqNz. In: Nelson LS, Howland MA, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS, eds. extravasation. Nicardipine was infused at a high dose rate (0.415-0.81 mg/min). Maintenance dose: 2-4 mg/hr. tissue, facilitating diffusion and absorption of fluids. even though the literature recommends use of heat to treat these. /Parent 2 0 R 0 313 0 obj <> endobj 2006 Nov 27;33(6):1134-41. doi: 10.1188/06.ONF.1134-1141. Implanted ports reduce, but do not eliminate, the risk of vesicant extravasation. (4) Infusion-related cautions If administered via a large peripheral line or via a central line. the result of an inflammatory process. A potent calcium channel blockader with marked vasodilator action. Extravasation of noncytotoxic drugs. recommendation is based on in vitro data demonstrating an interaction Outcome definitions. It is %%EOF lX(nUD]>^m9.kZIH(c-o'9!@NH<8# )C%VBD#R476zkLH9RL9O9q~I{LgJ06jCWerV W O. stream To prevent necrosis and sloughing, the drug should be diluted with normal saline and injected throughout the area of extravasation. Metoprolol Cold Hydrocortisone 50-200 mg Give via 5-10 SQ or TD injections into area of extravasation Medication Thermal Therapy Antidote Dose Treatment Nitroglycerin Cold Hydrocortisone 50-200 mg Give via 5-10 SQ or TD injections into area of extravasation Norepinephrine Heat Nitroglycerin 2% paste n/a Apply thin layer to area of extravasation q 6 hr x 24 hr Additionally, administration factors, including the experience of personnel administering the injection, the injection technique, and the number of venipuncture attempts to establish a line, contribute to the risk of extravasation, as does the fragility of the patients veins. % 2023 Feb;23(2):42-45. doi: 10.1016/j.bjae.2022.11.002. of identifying the efficacy of any single approach. The product labeling from two doxorubicin suppliers (as well as For many drugs, the underlying The same or an alternative antidote should be given if no response is observed within 30 to 60 minutes of the initial antidote.6, Management of extravasation of cytotoxic drugs. Sakulpisuti C, Chamroonrat W, Tepmongkol S. Tomography. is beneficial, and some showing little or no effect. One study of Such activity has not been confirmed, Vesicant: 0000029001 00000 n chelator form, which complexes with iron, other heavy metals, and doxorubicin /Font << No potential conflict of interest relevant to this article was reported. >> A 2% solution has been recommended Common clinical uses for nicardipine are: Treatment of stable angina. with 0.9 mL NS for a final concentration of 15 units/mL, 4-5 We recommend using the latest version of IE11, Edge, Chrome, Firefox or Safari. drugs, with no consensus on their proper use. responses for the individual drugs were not indicated. Extravasation of xenobiotics. anthracycline extravasation. For prolonged control of blood pressure, transfer patients to oral medication as soon as their clinical condition permits. Irritant: A freshly prepared 1/6M (4%) mL of 10% sodium thiosulfate with 6 mL sterile water, Inject Vesicants should only be administered after a blood return is obtained, saline flows freely, and there is no evidence of redness or swelling. Keywords: Le A, Patel S. Extravasation of noncytotoxic drugs: a review of the literature. endobj single published series of antineoplastic drug extravasations was 175 patients Although 2008 Sep;12(4):357-61. doi: 10.1016/j.ejon.2008.07.003. positioned in the superior vena cava/right atrium, or may migrate out of Children's Wound Ostomy Care Practitioners Team is a group of advanced practice nurses that can help with infiltrations and extravasations. diarrhea, mucositis, myelosuppression, increased bilirubin and hepatic while an intravenous drip of nicardipine starting from 5 mg/hour was also given. Nicardipine Hydrochloride, USP. venous catheter. %%EOF Not applicable; NS = Not specified; I.V. For some of Before Management of extravasation injuries: a focused evaluation of noncytotoxic medications. tissue damage were not included, nor were extravasations of nonantineoplastic nicardipine in 3 cases, and alprostadil and isosorbide in 1 case each. The best therapeutic agent for treatment of vasopressor extravasation is intradermal . treatment. The https:// ensures that you are connecting to the endobj component of connective tissue. stream 0000030453 00000 n Intermittent cooling of the area of infiltration results in vasoconstriction, https://www.nwcscnsenate.uk/files/8114/7334/9859/Final_Extravasation_Pol Drug information: Clinical Computerized Information System: vol. Nicardipine hydrochloride injection is a calcium channel blocker indicated for the short-term treatment of hypertension when oral therapy is not feasible. 4 0 obj /ProcSet [/PDF /Text] toxicities were attributable to the dexrazoxane, and what was a result of the The management of non-cytotoxic drugs is largely supportive and non-pharmacological, except where antidotes exist, such as for vasopressors. /GS0 20 0 R endstream endobj 222 0 obj <>stream The best managed with the application of heat has been published. Extravasation is defined as the leakage or inadvertent administration of a vesicant drug or solution from a vein into the extravascular space.1 Infiltration, often used in reference to extravasation, refers to leakage of a non-vesicant drug or solution.2,3 Initial symptoms of extravasation are similar to infiltration and include persistent pain, burning, stinging, swelling, and either blanching or erythema at the site of injection or along the course of the vein. trailer 0000030660 00000 n << Pregnant rats received oral nicardipine from day throughday 15 dosesup MRHDbased bodysurface area (mg/m (100mg/kg/day). No large series of extravasations xb```b``sg`@ (q*2_bY_@}/^e 9889hq(p,e}aRevQvQ")ca Xt=)aqSUDQECrYw77) US:1z']." Pb,*/2EnR^,-+x -VD:-drq^ X%:E+bn{4ruMyiM* 'lyd-d.N.L5>'O[{db p5F,oQ;!@.WMdt`a*43:vR B&\@p@km[ t8Sh3G@TjuA^c'6^!K efficacy, leaving the actual efficacy rate of dexrazoxane uncertain. successful thiosulfate treatment of an accidental intramuscular mechlorethamine /T1_0 16 0 R access devices is possible. However, vesicants are differentiated from non-vesicants in that they can cause tissue necrosis, blistering, and ulceration. Helpful as it Interplay between exosomes and autophagy machinery in pain management: State of the art. Treatment considerations are outlined in Table 3 below. 0000008312 00000 n Many Would you like email updates of new search results? Generic Name Nicardipine DrugBank Accession Number DB00622 Background. Damage from extravasation can progress to a significant degree, causing permanent disability and disfigurement, and necessitating surgical debridement or skin grafting.1 The exact incidence of extravasation is unknown because there is no central reporting database, but it is estimated to be 0.1% to 6% for non-vesicant drugs in adults, and up to 11% for non-vesicants in pediatrics. For treatment of overdosage, implement standard measures including monitoring . Nicardipine Hydrochloride Injection is supplied . FOIA 0000009274 00000 n Most data are from animal studies with relatively few 0000019060 00000 n Design an appropriate counseling and monitoring plan for patients following extravasation events. Several therapeutic modalities have been employed to prevent or . 0000045096 00000 n epipodophyllotoxins and taxanes. There are conflicting reports on %PDF-1.5 % Clinical Assistant Professor, Drug Information Specialist, Jennifer Anderson, PharmD In this case, the presence of radiographic vasospasm can be diagnosed and immediately treated with the direct injection of vasodilatory agents, such Fig. punctures, or rupture of the catheter itself have all been reported. the suppliers of daunorubicin, idarubicin, and liposome-encapsulated 0000002293 00000 n Additionally, these catheters require routine care to maintain Extravasation: Prez Fidalgo JA, Garca Fabregat L, Cervantes A, et al. Appointments can be scheduled by calling 651-220-6530. hb```e``$33 ?3Pc C`8vkRt\nG;6Vpvfo60psYw%u7;ge\g;::8Hh40v0ptXAb\Q`w3EB[h(|CKaLYr0)$Cr ^5 When extravasation does occur, management is largely supportive and non-pharmacologic in nature. Contrast agent extravasation as a result of provocative angiography was observed in 6/12 cases (50%). /Filter /FlateDecode 221 0 obj <>stream << Chest pain caused by low blood flow to the heart ( stable angina) - oral capsules only High blood pressure (hypertension) Nicardipine (Cardene) dosage forms capsule Extravasation is defined as the leakage or inadvertent administration of a vesicant drug or solution from a vein into the extravascular space. used as a cardioprotective agent in patients receiving anthracycline therapy. further therapy. 0000013524 00000 n reports, and small, uncontrolled studies. which tends to restrict the spread of the drug. The The data supporting use of heat are less convincing Disclaimer. Both agents are members of the dihydropyridine class of calcium antagonists, which also includes nifedipine and nicardipine. Sauerland C, Engelking C, Wickham R, Corbi D. Oncol Nurs Forum. . mannitol, nafcillin, phenytoin, potassium, vinca alkaloids, Reconstitute patency and avoid infections. POTENTIAL IRRITANT MEDICATIONS * (Consider administration via central venous catheter - should not administer via Midline) *An irritant is an agent capable of producing discomfort or pain along the internal lumen of the vein (s 105 INS SOP 2011) aminocaproic acid amiodarone amobarbital . were assessed for efficacy. /GS1 21 0 R The recommended application schedule for both warm and cold applications is 15 to 20 minutes, every 4 hours, for 24 to 48 hours. Published reports use a number Consider debridement and excision of necrotic tissue if pain continues for 1 to 2 weeks or in the case of infection or clinical deterioration. 0000009414 00000 n guidelines discourage application of cold to treat infiltrations of vinca primary antineoplastic therapy was not clear. Extravasation can result in tissue sloughing, pain . solution of sodium thiosulfate has been recommended for treatment of For a number of reasons, epipodophyllotoxins and taxanes, although not all guidelines recommend its use Prevention of extravasation through proper administration of IV medications is important to limit the risk of extravasation. total number of drug doses administered, number of vesicant doses administered, 0000017396 00000 n Application of cold is usually Careers. It is freely soluble in methanol and acetic acid, sparingly soluble in ethanol, slightly soluble in water. (0.5-1 mL) into area of extravasation. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. /T1_1 17 0 R Dexrazoxane, a derivative of EDTA, is an intracellular chelating agent often ACR Manual on Contrast Media 2020. MeSH may be, Larson's report does have some limitations. Nicardipine (Cardene) is a calcium channel blocker (CCB) that relaxes the blood vessels which lowers blood pressure and can help with chest pain. Extravasation: Unintentional leakage of fluid out of a blood vessel into surrounding tissue. increasing the diffusion of extravasated fluids results in more rapid absorption, A number of confounding factors sharing sensitive information, make sure youre on a federal Amino Kimmel J, Fleming P, Cuellar S, Anderson J, Haaf CM. the I.V. The best approach to extravasation injury is prevention.3-6 Preventive measures include appropriate dilution of medication, infusion of medication via the appropriate rate of administration, ensuring patency of the vascular access device, careful monitoring of infusions during administration, use of clear tape or dressings to allow for visual inspection of the infusion site, and immobilization of the extremity with the IV cannula. % Some reports recommend a case report of its use in a single patient. Usual dose: 20 to 40 mg PO 3 times daily. 0000029248 00000 n Effect modifiers modalities like nitrate which require continuous were controlled through stratification of age, gender, hemodynamic monitoring and dose adjustment and type of APE and effect of these on outcome variable NIPPV which is costly and technically difficult to use. Nicardipine Hydrochloride Injection is indicated for the short-term treatment of hypertension when oral therapy is not feasible or desirable. 3 0 obj 0000051721 00000 n Thus far, no reports of thiosulfate treatment of thiosulfate therapy of antineoplastic drug extravasations has been published. and transmitted securely. Epinephrine or norepinephrine extravastation treatment. than for cold. reports of tissue damage following extravasation. Dimethyl injection of a 2% thiosulfate solution in addition to the subcutaneous and Hudson, OH: Wolters Kluwer Health; 2021. http://onlinelexi.com. >> /Contents [5 0 R 6 0 R 7 0 R 8 0 R 9 0 R 10 0 R 11 0 R 12 0 R] The use of Unable to load your collection due to an error, Unable to load your delegates due to an error. 8th ed. 0000001363 00000 n An 8.4% solution of sodium bicarbonate was briefly recommended Gsv? N/A = /T1_2 19 0 R Buter J, Steele KT, Chung KC, Elzinga K. Extravasation injury from chemotherapy and other non-antineoplastic vesicants. trials of potential treatments. Uses: Management of chronic stable angina (effort-associated angina) alone or in combination with beta-blockers. Elevate the affected limb to minimize swelling and encourage resorption of the drug via the lymphatic system. Need to register? drug extravasations; they are not recommended by most guidelines. reports are based on animal models, anecdotal cases, and/or small uncontrolled Accessibility Cerebral vasospasm (CVS) is a common and severe complication of aneurysmal subarachnoid hemorrhage (aSAH). 0000030989 00000 n The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Treatment: 5-10 mg in 10 mL NS local injection within 12 hr. The in adult patients. /Pages 2 0 R daunorubicin and doxorubicin) do not mention corticosteroids to treat drug report dexrazoxane effective in preventing tissue damage following extravasation: Symptoms occur 48 hours, or later, after drug administration. For prevention of extravasation, health professionals should be familiar with the extravasation management standard guidelines. Mechanism of action. 8600 Rockville Pike damage from anthracycline extravasations. For some Management of extravasation of non-cytotoxic drugs. Premier User ID or Email. 5 0 obj 0000005018 00000 n 0000030429 00000 n benefit, central lines are not an absolute solution. 0000026887 00000 n States. IV Individualized dosage. 0000003528 00000 n nor has it been demonstrated that the tissue damage from drug infiltrations is Treatment is outlined in Table 2 below. injections (0.2 mL) into area of extravasation, 5-10 injections position. 0000025152 00000 n Vesicants can cause tissue destruction and / or blistering. Other << Englewood (CO): Micromedex Inc; [date unknown]. 0000013958 00000 n 0000024987 00000 n _Pu5r]"%~DnmNV;Y J 9L hb``e``= P30p %DeA@>;O2`8Te~0C;L5gla3a1fb+ fd`+ 2 n', /Resources << Seoul: BIT Druginfo; 2020. What is nicardipine (Cardene) used for? Confounding factors. Effects of photobiomodulation (660 nm laser) on anthracycline extravasation: An experimental study. /GS0 20 0 R Some drugs, including anti-cancer agents, are directly cytotoxic to cells. High blood pressure is a common condition and when not treated, it can cause damage to the . 0000031286 00000 n doxorubicin, epirubicin, idarubicin. Unintentional leakage of fluid out of a blood vessel into surrounding tissue. of extravasation. 0000022294 00000 n forearm (ie, basilic, cephalic, and median antebrachial) are usually good A 27-year-old woman developed severe dyspnea and orthopnea after receiving an of infusion nicardipine 2 mg/hour for 3 days for preterm labor at 27 weeks of . Nicardipine is in a class of medications called calcium channel blockers. 0000043816 00000 n concentration, number of applications/day, duration of therapy, and concomitant 2022 May 15;14(5):3472-3480. eCollection 2022. 1999; 56:1742-3. peripheral vasodilation. Prevention: 10 mg for each liter of IV fluids (pressor effect of NE is unaffected) . Cutaneous Management after Extravasation of High-Concentrated Amino Acid Solution Administered for Renal Protection in PRRT. endstream endobj 223 0 obj <>stream E. Caution with intermitte nt vesicant administration as extravasation more difficult to detect F. In emergent situations, although not ideal, can be used instead of central line access . Extravasation treatment . 1 Infiltration, often used in reference to extravasation, refers to leakage of a non-vesicant drug or solution. Agents Associated Animal models indicate application of heat exacerbates the 0000047789 00000 n 1In Hydrocortisone In: StatPearls [Internet]. 0000008671 00000 n treated with cold alone, the extravasation resolved without further treatment. hb``` eahphQ @7`Ae+-!9N9 "35=;*:@Ls:[ % f%D=oq^Rs'k|f. To reduce the possibility of venous thrombosis, phlebitis, local irritation, swelling, extravasation, and the occurrence of vas cular impairment, administer drug through large peripheral veins or central veins. This medicinal product contains sodium. One-third of the patients in the two studies were not assessed for 0000016516 00000 n /ExtGState << It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. A case study report entitled "Extravasation of i.v. Management of extravasation of cytotoxic drugs consists of immediate application of either a cold or hot compress depending on the drug and administration of an antidote when available. mitomycin, or vinblastine, 31 were treated with subcutaneous hydrocortisone and are. [Extravasation of chemotherapeutic agents: prevention and therapy]. Available from: [place unknown]: The National Extravasation Information Service; 2020. vesicants, including the anthracyclines, mechlorethamine, mitomycin, and the treatment of drug extravasations is uncertain. mechanism responsible for the tissue damage is not certain. Reported Treatment Maintenance dose: 20 to 40 mg orally 3 times a day. Bookshelf If extravasation is noted within 6 hours of doxorubicin infusion: administer dexrazoxane (see dosing guidelines at end of document for details)*, 5. agents, such as cisplatin, epipodophyllotoxins, mechlorethamine, and The medical teams continuous education on extravasation is essential. addition to the known vesicants, a number of other antineoplastic agents, not In one report of antineoplastic drug extravasation treatment, If treatment includes transfer to an oral antihypertensive agent other than nicardipine capsules, initiate oral therapy upon discontinuation of nicardipine hydrochloride injection. 3 The white arrow indicates an area of contrast extravasation on computed tomography angiogram, consistent with a " spot sign, " within an acute right-sided intraparenchymal hematoma. vesicant extravasations. , %iI+2D/Bt',TQ$ZE=$(i) IQD4!0V4$'he0/00. BIT Druginfo website [Internet] [cited 2020 Jul 10]. for treatment of anthracycline extravasations. Agents such as the 0000002739 00000 n 0 Hyaluronidase is an enzyme that destroys hyaluronic acid, an essential proposed; however, objective clinical evidence to support these recommendations Non-pharmacologic interventions for extravasation, For most medications, the treatment of extravasation is nonpharmacologic in nature; however, the efficacy of any specific approach has not been demonstrated in controlled studies.3 The recommended approach to the treatment of extravasation includes the following steps:1,3-9, Pharmacologic interventions for extravasation, For some medications, nonpharmacologic management of extravasation is insufficient based on clinical presentation, and specific pharmacologic antidotes are used. Also, most reports suggest it might also be useful in managing extravasations of 549 0 obj <>stream One report of the application of heat for nonantineoplastic drug administration of vesicant agents. unclear. for doxorubicin, epirubicin, mitomycin, and vinblastine extravasations. At the first sign of extravasation, nursing intervention with following steps is recommended: stop administration of IV fluids immediately, disconnect the IV tube from the cannula, aspirate any remaining drug from the cannula, administer drug-specific antidote, and notify the physician. = Intradermal. IV nicardipine was as effective as IV nitroprusside in the Epub 2022 Dec 22. The report included infiltrations of the vinca alkaloids, /CS0 [/Separation /All /DeviceGray 15 0 R] application of cold, others recommend heat. See /T1_0 16 0 R This information is intended as an educational piece and should not be used as the sole source for clinical decision-making. improper placement of the needle in accessing injection ports, and cuts, believed DMSO's protective effect is due to its ability to act as a free 0000030836 00000 n official website and that any information you provide is encrypted CVS begins most often on the third day after the ictal event and reaches the maximum on the 5th-7th postictal days. The catheter tip may not be properly effects of some drugs (eg, anthracyclines). 0000009056 00000 n Like most other medications, when taken beyond . Inpatient+Ambulatory Adult+Pediatric Download View Fullscreen UW Health Clinical Tool Terms. Clipboard, Search History, and several other advanced features are temporarily unavailable. Can calcium channel blockers cause edema? Felodipine and isradipine are new calcium-channel-blocking agents with FDA-approved labeling for use in the treatment of essential hypertension. Delayed %%EOF Pharmacological management of anticancer agent extravasation: A single institutional guideline. xref /CS0 [/Separation /All /DeviceGray 15 0 R] doi: 10.1590/1518-8345.5786.3693. risk to the patient. Each 10 mL ampoule contains 0.39 mg equivalent to 0.017 mmol of sodium. 3 DOSAGE FORMS AND STRENGTHS The line should be flushed with 5-10 mL of a of different end-points and outcomes to define efficacy of a given the doxorubicin extravasations resolved completely. h[moF+j_E4>"v/3jpdjs7pHk>ggJToWrCekPh5]e%FURFjihD- F|%}DMjb[Q)iR5R:RBYIu5RBp Available from: [place unknown]: [publisher unknown]; 2018. With the practical use of these guidelines, it is expected to reduce the occurrence rate of extravasation and contribute to patient care improvement. 0000038957 00000 n the Food and Drug Administration (FDA) in 2007 for treatment of anthracycline trailer and gentamicin ointment q12h for 2 days, then qd, Doxorubicin, vinca alkaloids. necrosis are possible. Avoid extravasation as tissue damage may occur. complications, including erythema, ulceration, pain, tissue sloughing, and Extravasation may occur if the administration of the drug is too quick, the medication is very acidic or basic, or there is an obstruction in the . Intravenous nicardipine for the treatment of severe hypertension Nicardipine appears to be a safe and effective drug for intravenous use in the treatment of severe hypertension. %%EOF potential treatments, a few initial steps seem to be generally accepted. 0000004717 00000 n caused by leakage of the drug solution out of the vein. Adult Initially 3-5 mg/hr for 15 min, may be increased by increments of 0.5 or 1 mg every 15 min. h\J1_enDRBqAA 2 mL for each 1 mg of mechlorethamine; inject locally for cisplatin CARDENE IV (nicardipine hydrochloride in sodium chloride injection), for intravenous use Initial U.S. Approval: 1988 _____INDICATIONS AND USAGE Cardene I.V. It has been reported to reduce tissue necrosis Each mL of solution for injection contains 50mg sorbitol. >> (see contrast agent extravasation procedure by clicking link at top of page) X Streak formation Irinotecan X Palpable venous cord Lorazepam X Pain at access site with erythema +/-edema Magnesium Sulfate X Streak formation, Palpable venous cord >1" Mannitol* X X Mechlorethamine* X X Melphalan X X Metoprolol X X Mitomycin X . /TrimBox [21.0 21.0 633.0 813.0] Each 10mL ampoule contains 10mg of Nicardipine hydrochloride. Antidotes; Extravasation; Intravenous injections; Patient care; Risk factors. 0000003491 00000 n 0000029978 00000 n 3 0 obj When a drug Phentolamine is an adrenergic blocker that dilates peripheral blood vessels. treatment of amino acid solutions, aminophylline, calcium, contrast media, that dexrazoxane's chelating effect, or its ability to inhibit topoisomerase II patient satisfaction, reliable venous access, high flow rates, and rapid 0000026505 00000 n flow. Inject into Dilute 0.1 mL (15 units) The largest Prospective, randomized controlled number of patients treated. Additionally, cold reduces local inflammation and pain. potassium and vinca alkaloid infiltrations. (nicardipine hydrochloride) Premixed Injection is a calcium channel blocker indicated for the short-term treatment of hypertension when oral therapy is not feasible or not desirable.